What is the antibiotic of choice for treating syphilis?

Penicillin G is the antibiotic of choice for treating syphilis because it is highly effective against the bacterium Treponema pallidum, which causes the infection. Penicillin has a well-established history of success in treating syphilis, particularly in its various stages, including primary, secondary, and tertiary syphilis.

The use of Penicillin G is supported by clinical guidelines and extensive research, making it the gold standard in treatment. Moreover, it has the capability to penetrate effectively to the site of infection and is typically administered via injection, ensuring adequate levels of the drug in the bloodstream to combat the infection.

In contrast, the other options listed do not have the same level of efficacy against Treponema pallidum. Amoxicillin, while a penicillin-type antibiotic, is not the first-line treatment for syphilis. Ciprofloxacin and tetracycline, while effective against other bacterial infections, are not recommended for treating syphilis due to lower efficacy and potential resistance issues. Therefore, Penicillin G remains the definitive choice for syphilis treatment due to its proven effectiveness and long-standing use in medical practice.