What progressive neurological disorder typically causes motor dysfunction?

Severe Parkinson's Disease is a progressive neurological disorder primarily known for causing significant motor dysfunction. In Parkinson’s disease, the degeneration of dopamine-producing neurons in the brain leads to symptoms such as tremors, rigidity, bradykinesia (slowness of movement), and postural instability. These motor deficits can progressively worsen as the disease advances, severely impacting the individual's ability to perform daily activities.

While other conditions listed, such as Multiple Sclerosis and Amyotrophic Lateral Sclerosis, can also involve motor dysfunction, they have distinct characteristics and a broader spectrum of symptoms including cognitive changes and sensory issues. Alzheimer's Disease mainly affects cognitive function and memory, and does not primarily cause motor dysfunction as its main characteristic. Thus, severe Parkinson's Disease stands out for its clear and primary association with motor impairments.