When do ACEI induced coughs typically start after the initiation of treatment?

ACE inhibitor-induced coughs typically begin within the first few weeks after starting the medication, commonly around the two-week mark. This time frame can vary by patient, but it's generally in the range of one to three weeks post-initiation of therapy. The cough is thought to arise due to the accumulation of bradykinin, a peptide that can increase in concentration due to the inhibition of angiotensin-converting enzyme, leading to irritation of the respiratory tract. Recognizing this onset is crucial for healthcare providers to manage the patient's treatment effectively and address any side effects promptly.