Which factor can lead to the development of angular cheilitis?

The development of angular cheilitis is often associated with dehydration. This condition manifests as cracks or sores at the corners of the mouth, and it can occur when the skin in that area becomes dry and fissured. Dehydration, whether due to insufficient fluid intake, certain medications, or underlying health issues, contributes to this dryness, making the skin more prone to irritation and breakdown. Additionally, when the corners of the mouth are often wet from saliva, dehydration can exacerbate the risk, as the moisture can lead to maceration around the cracks, creating a breeding ground for pathogens.

In contrast, increased hydration typically helps maintain skin integrity and moisture levels, reducing the risk of conditions like angular cheilitis. Allergic reactions could cause similar symptoms but are not a primary contributing factor to this specific condition. Genetic predisposition may influence overall skin health but does not directly lead to the acute development of angular cheilitis as dehydration does. Therefore, the link between dehydration and the development of angular cheilitis is the most significant factor in this context.