Which of the following is associated with weight gain as a side effect?

Tricyclic antidepressants are indeed associated with weight gain as a common side effect. This class of medications can affect various neurotransmitters and may influence appetite regulation. The sedative properties of many tricyclics can also lead to increased fatigue and a tendency to lead a more sedentary lifestyle, contributing to weight gain.

In addition, these medications often change metabolic processes and can increase cravings for carbohydrates, further influencing weight. This is particularly important for patients to understand, as weight gain can impact their overall health and adherence to treatment. It's essential for practitioners to monitor patients for this side effect and offer guidance on lifestyle modifications if needed.